Senior Scientist, Clinical Pharmacology & Quantitative Science

At Genmab, we are dedicated to building extra[not]ordinary® futures, together, by developing antibody products and groundbreaking, knock-your-socks-off KYSO antibody medicines® that change lives and the future of cancer treatment and serious diseases. We strive to create, champion and maintain a global workplace where individuals’ unique contributions are valued and drive innovative solutions to meet the needs of our patients, care partners, families and employees.

Our people are compassionate, candid, and purposeful, and our business is innovative and rooted in science. We believe that being proudly authentic and determined to be our best is essential to fulfilling our purpose. Yes, our work is incredibly serious and impactful, but we have big ambitions, bring a ton of care to pursuing them, and have a lot of fun while doing so.

Does this inspire you and feel like a fit? Then we would love to have you join us!

• Leads pharmacology activities within assigned programs, including study design, data analysis, interpretation, and reporting, to inform key development decisions.
• Provides pharmacology expertise to multidisciplinary Compound Development Teams and other functions across Genmab.
• Defines and executes PK/PD modelling and simulation plans to guide clinical candidate selection, first-in-human (FIH) dose projection, dose escalation, recommended phase 2 dose selection, and further clinical development.
• Develops and refines platform PBPK and/or QSP models to characterize proprietary antibody technologies and inform candidate selection and clinical dose projections.
• Takes responsibility for TK, PK, and PD evaluation and reporting in assigned nonclinical studies.
• Provides expert pharmacology input into nonclinical and regulatory documents, including study reports, IND/CTA submissions, clinical trial protocols, and investigator brochures, within agreed timelines.

• A MSc, PharmD or PhD in Clinical Pharmacology, Pharmacology, Pharmacokinetics, or related discipline is required.
• Approximately 2 of experience in pre-clinical and/or clinical pharmacology in pharma, biotechnology, or consulting.
• Experience in PK and PK/PD data analysis, including noncompartmental analysis and allometric scaling.
• Demonstrated ability to develop and apply mechanistic PK/PD models, particularly PBPK and/or QSP models, to inform drug development decisions.
• Hands-on programming experience in R or a comparable scientific programming language is required; experience with NONMEM, Phoenix WinNonlin, or other PK/PD analysis software is preferred.
• An understanding of antibody therapeutics development and experience in the field of oncology or immunology are considered beneficial.
• A proactive and adaptable approach, with the ability to collaborate across disciplines, prioritize effectively, and communicate scientific findings clearly in writing and verbally.
• Excellent written, verbal, and interpersonal communication skills in English.
• You currently live in the Netherlands, within commuting distance of Utrecht for hybrid working and you are available to start no later than January 1, 2027.

The proposed gross annual/monthly base salary range for this position, in the primary location, based on a full time schedule is:

The final salary offer will depend on several factors, including your skills, qualifications, and experience.

In addition to base salary, this position is eligible for additional forms of compensation, such as discretionary bonuses and long-term incentives.

When you join Genmab, you become a part of a culture that supports your physical, financial, social, and emotional well-being. Our benefits include, but are not limited to:

• Pension
• Health insurance and wellness benefits
• Paid time off
• Employee support programs

Further details on eligibility for compensation and benefits based on the role will be provided during the recruitment process.

Genmab is an international biotechnology company with a core purpose to improve the lives of patients through innovative and differentiated antibody therapeutics. For 25 years, its hard-working, innovative and collaborative team has invented next-generation antibody technology platforms and harnessed translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO®) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X.

Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website Job Applicant Privacy Notice (genmab.com).

Please note that if you are applying for a position in the Netherlands, Genmab’s policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the contract.

The Clinical Pharmacology and Quantitative Science department is responsible for designing and executing strong modeling and simulation strategies to guide dose and schedule recommendations across all phases of drug development. In addition, we create models based on drug, disease and trial information to better understand and explore molecule and platform properties.

The (Senior) Scientist, Clinical Pharmacology & Quantitative Science will provide pharmacology expertise to programs through all stages of research and development, with a focus on early-stage assets. You will be responsible for defining a translational modelling and simulation strategy and leads cross-functional project teams tasked with executing this strategy, to determine the appropriate route of administration, dose levels, dosing regimens for first-in-human (FIH) clinical trials.

In this role, you generate an in-depth understanding of all aspects of PK and PD of Genmab’s current and future antibody technologies, building and refining platform PBPK and QSP models and applying these models to guide rational experimental designs and critical decisions on candidate antibody therapies. This is an exciting opportunity to be part of a passionate, high profile, high-impact Clinical Pharmacology & Quantitative Science team, and to work in a highly dynamic and collaborative setting, with opportunities for professional development.

This position is a temporary maternity leave cover, and therefore we offer a 6 month - fixed-term contract.